Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13548738 | 0.80 | ALOX5AP (0.38) | ALOX5APHSD11B1PDK2 | |
| SCHEMBL3582800 | 0.77 | ALOX5AP (0.51) | ALOX5APHSD11B1 | |
| SCHEMBL23342649 | 0.75 | PDK2 (0.38) | ALOX5APHSD11B1PDK2GAA | |
| SCHEMBL87608 | 0.75 | HSD11B1 (0.55) | ALOX5APHSD11B1 | |
| SCHEMBL3859941 | 0.74 | HSD11B1 (0.42) | ALOX5APHSD11B1HDAC4OPRL1P2RX7 | |
| SCHEMBL3864329 | 0.73 | ALOX5AP (0.33) | ALOX5APHSD11B1P2RX7BACE1PSEN1 | |
| SCHEMBL3861571 | 0.73 | ALOX5AP (0.33) | ALOX5APHSD11B1P2RX7BACE1PSEN1 | |
| SCHEMBL3861576 | 0.73 | ALOX5AP (0.33) | ALOX5APHSD11B1P2RX7BACE1PSEN1 | |
| SCHEMBL13548739 | 0.73 | ALOX5AP (0.34) | ALOX5APHSD11B1EPHX2 | |
| SCHEMBL23342513 | 0.73 | SLC6A3 (0.38) | ALOX5APOPRM1SIGMAR1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703799-B2 | Non-competitive NMDA receptor antagonists | ADEJARE ADEBOYE (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120129889-A1 | Non-competitive NMDA receptor antagonists | ADEJARE ADEBOYE (US) | 2012-05-24 | — | — | US | disclosed |
| US-8129414-B2 | Non-competitive NMDA receptor antagonists | Adejare, Adeboye (US) | 2012-03-06 | — | — | US | disclosed |
| US-20080039498-A1 | Non-competitive NMDA receptor antagonists | ADEJARE ADEBOYE | 2008-02-14 | — | — | US | disclosed |
| WO-2007149508-A2 | NON-COMPETITIVE NMDA RECEPTOR ANTAGONISTS | THE UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039498-A1 | Non-competitive NMDA receptor antagonists | GRIN1, GRIN3A, GRIN2A | ALOX5AP 1234/4885HSD11B1 4199/4885HDAC4 2265/4885 |
| US-20120129889-A1 | Non-competitive NMDA receptor antagonists | GRIN1, GRIN3A, GRIN2A | ALOX5AP 1234/4885HSD11B1 4199/4885HDAC4 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.