Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8761342 | 0.92 | LSS (0.42) | LSS | |
| SCHEMBL8760852 | 0.80 | LSS (0.55) | LSSKDM4E | |
| SCHEMBL8478710 | 0.80 | LSS (0.46) | LSSROCK1KDM1AEP300 | |
| SCHEMBL8760778 | 0.80 | LSS (0.44) | LSSKDM4EALDH1A1HPGDSCN9A | |
| Fumaric Acid SCHEMBL8761348 | 0.74 | LSS (0.43) | LSSSCN9A | |
| Fumaric Acid SCHEMBL8484063 | 0.73 | LSS (0.44) | LSSROCK1 | |
| SCHEMBL8478712 | 0.70 | LSS (0.50) | LSSROCK1SCN9AKDM1AEP300 | |
| SCHEMBL8478588 | 0.70 | LSS (0.66) | LSSKDM4E | |
| SCHEMBL8484409 | 0.69 | LSS (0.55) | LSSROCK1KDM4EALDH1A1HPGD | |
| SCHEMBL8760860 | 0.69 | LSS (0.68) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | claimed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |