Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879037 | 0.85 | SMN1; SMN2 (0.53) | KMT2AMEN1GLAPOLBTP53 | |
| SCHEMBL3227479 | 0.81 | CA12 (0.47) | ADRB2ADRB1ADRB3PKMKMT2A | |
| SCHEMBL8879442 | 0.80 | KCNA1 (0.58) | PKMRAB9ATP53MAPTFBP1 | |
| SCHEMBL27405440 | 0.79 | RAB9A (0.51) | ADRB2ADRB1KMT2AMEN1RAB9A | |
| SCHEMBL7993384 | 0.78 | KCNA1 (0.51) | PKMKMT2AMEN1RAB9ATP53 | |
| SCHEMBL15739728 | 0.77 | ROCK1 (0.52) | PKMKMT2AMEN1RAB9AGLA | |
| SCHEMBL3200431 | 0.76 | POLB (0.43) | ADRB2ADRB1ADRB3PKMKMT2A | |
| SCHEMBL28457831 | 0.76 | CA1 (0.56) | PKMKMT2AMEN1GLAPOLB | |
| SCHEMBL38660212 | 0.76 | POLB (0.43) | ADRB2ADRB1ADRB3PKMKMT2A | |
| SCHEMBL9394422 | 0.75 | CA1 (0.43) | ADRB2ADRB1ADRB3PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614887-B1 | Indole-sulfonamides as antitumor agents | LILLY CO ELI (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1994020101-A1 | ANTITUMOR COMPOSITIONS AND METHODS OF TREATMENT | ELI LILLY AND COMPANY (US) | 1994-09-15 | — | — | WO | disclosed |
| EP-0614887-A1 | Indole-sulfonamides as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-09-14 | — | — | EP | disclosed |