Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 6/20 | 0.51 |
| ▸ | KCNAB1 | Q14722 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879442 | 0.89 | KCNA1 (0.58) | KCNA1KCNAB1RAB9ANPC1TP53 | |
| SCHEMBL8761107 | 0.84 | KCNA1 (0.46) | KCNA1KCNAB1RAB9AMAPTPTPN11 | |
| SCHEMBL8879166 | 0.80 | KCNA1 (0.56) | KCNA1KCNAB1RAB9ANPC1MAPT | |
| SCHEMBL8761004 | 0.78 | ADRB2 (0.49) | RAB9ATP53PKMTSHRFBP1 | |
| SCHEMBL8761266 | 0.77 | PKM (0.60) | KCNA1KCNAB1RAB9APKMMAPT | |
| Ly-295501 SCHEMBL30351 | 0.76 | PKM (0.58) | KCNA1KCNAB1RAB9ANPC1PKM | |
| Ly-295501 SCHEMBL29375534 | 0.76 | PKM (0.58) | KCNA1KCNAB1RAB9ANPC1PKM | |
| SCHEMBL8761148 | 0.76 | PKM (0.51) | KCNA1KCNAB1NPC1PKMFBP1 | |
| SCHEMBL9487998 | 0.75 | KMT2A (0.76) | KCNA1KCNAB1RAB9ANPC1TP53 | |
| SCHEMBL9097173 | 0.75 | MEN1 (0.57) | NPC1MAPTSMN1; SMN2BLMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281240-B1 | CYSTIC FIBROSIS | ELI LILLY AND COMPANY | 2001-08-28 | — | — | US | disclosed |
| WO-1998044799-A1 | DIARYLSULFONYLUREAS FOR USE IN TREATING SECRETORY DIARRHEA | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0606723-A1 | Imidazolidin-2-one derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5270329-A | 1-arylsulfonyl-imidazolidin-2-one derivatives | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |