Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8748821 | 1.00 | LMNA (0.46) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL8749104 | 0.89 | CNR1 (0.46) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL9470400 | 0.88 | LMNA (0.43) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL8749180 | 0.87 | CNR1 (0.49) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL8749222 | 0.86 | CNR1 (0.53) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL9347499 | 0.86 | CNR1 (0.44) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL9347494 | 0.86 | CNR1 (0.44) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL8749203 | 0.85 | CNR1 (0.55) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL8749158 | 0.85 | CNR1 (0.55) | LMNACNR1DAGLAGAATSHR | |
| SCHEMBL7635759 | 0.84 | LMNA (0.47) | LMNACNR1DAGLAGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4774255-A | SKIN DISORDERS | LEVER BROTHERS COMPANY (US) | 1988-09-27 | — | — | US | claimed |
| EP-0446047-B1 | Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors | UNILEVER PLC (GB) | 1997-06-11 | — | — | EP | disclosed |
| US-5411978-A | Aging resistance, human skin | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5338747-A | Benzoisothiazolinone-1-dioxide derivatives as elastase inhibitors | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1994-08-16 | — | — | US | disclosed |
| EP-0446047-A1 | Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors | UNILEVER PLC (GB) | 1991-09-11 | — | — | EP | disclosed |