Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9015591 | 0.99 | CYP3A4 (0.45) | CYP3A4CYP2C19GAARECQLL3MBTL1 | |
| SCHEMBL8762105 | 0.82 | CYP3A4 (0.50) | CYP3A4CYP2C19GAARECQLL3MBTL1 | |
| SCHEMBL9015671 | 0.82 | POLB (0.42) | CYP3A4CYP2C19GAARECQLTSHR | |
| Hydrochloric Acid SCHEMBL9015589 | 0.81 | CYP3A4 (0.49) | CYP3A4CYP2C19GAARECQLL3MBTL1 | |
| SCHEMBL8761068 | 0.72 | CYP3A4 (0.36) | CYP3A4CYP2C19GAARECQLUSP2 | |
| SCHEMBL1221538 | 0.69 | LMNA (0.42) | CYP3A4CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1221603 | 0.69 | ALDH1A1 (0.47) | RECQLL3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL7848308 | 0.68 | POLB (0.45) | GAAL3MBTL1ALDH1A1KDM4EHTT | |
| SCHEMBL27974457 | 0.68 | USP2 (0.53) | CYP3A4CYP2C19GAARECQLL3MBTL1 | |
| SCHEMBL2327387 | 0.68 | USP2 (0.53) | CYP3A4CYP2C19GAARECQLL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777475-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0777475-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006609-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-03-07 | — | — | WO | disclosed |