Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.54 |
| ▸ | CA12 | O43570 | 9/20 | 0.54 |
| ▸ | CA1 | P00915 | 9/20 | 0.54 |
| ▸ | CA9 | Q16790 | 9/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000981 | 0.88 | CA12 (0.53) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL9487105 | 0.84 | MEN1 (0.62) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL9486495 | 0.83 | CA12 (0.66) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL8762861 | 0.82 | PPARG (0.52) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL8762900 | 0.81 | CA12 (0.57) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL8762903 | 0.80 | CA12 (0.56) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL9529388 | 0.79 | LMNA (0.63) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL9487941 | 0.78 | FBP1 (0.79) | CA2CA12CA1CA9MEN1 | |
| SCHEMBL9486556 | 0.78 | MEN1 (0.67) | CA2CA12CA1CA9MEN1 | |
| Ly-181984 SCHEMBL4612056 | 0.77 | RECQL (0.74) | CA2CA12CA1CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550157-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | claimed |
| EP-0550157-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-07-07 | — | — | EP | claimed |
| EP-0550157-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5354778-A | N-Phenyl-N'-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| US-5234955-A | N-phenyl-N*-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0550157-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |