Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 4/20 | 0.58 |
| ▸ | CA1 | P00915 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA9 | Q16790 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186566 | 0.94 | LMNA (0.72) | LMNAMEN1KMT2ACYP2C9FBP1 | |
| SCHEMBL9486495 | 0.92 | CA12 (0.66) | LMNAMEN1KMT2AFLT1FLT4 | |
| SCHEMBL4196236 | 0.88 | LMNA (0.78) | LMNACYP2C9FBP1CA12CA1 | |
| SCHEMBL9487941 | 0.86 | FBP1 (0.79) | MEN1KMT2AFBP1FLT1FLT4 | |
| SCHEMBL9068784 | 0.86 | FLT1 (0.58) | LMNAMEN1KMT2ACYP2C9FLT1 | |
| SCHEMBL7285851 | 0.86 | FLT1 (0.58) | LMNAMEN1KMT2ACYP2C9FLT1 | |
| SCHEMBL8074022 | 0.85 | CNR1 (0.52) | LMNAMEN1KMT2ACYP2C9FBP1 | |
| SCHEMBL8074014 | 0.85 | CNR1 (0.52) | LMNAMEN1KMT2ACYP2C9FBP1 | |
| SCHEMBL6297294 | 0.85 | LMNA (0.79) | LMNAMEN1KMT2ACYP2C9CA12 | |
| SCHEMBL9096201 | 0.84 | ALDH1A1 (0.60) | LMNAMEN1KMT2AFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |