Biotin

Biotin

SCHEMBL8763

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 6/20 1.00
MEN1 O00255 1/20 1.00
ABL1 P00519 1/20 1.00
LMNA P02545 1/20 1.00
PKM P14618 1/20 1.00
IDE P14735 1/20 1.00
MAPK1 P28482 1/20 1.00
KMT2A Q03164 1/20 1.00
RIN1 Q13671 1/20 1.00
L3MBTL1 Q9Y468 1/20 1.00
HLCS P50747 6/20 0.69
CA12 O43570 7/20 0.56
CA1 P00915 7/20 0.56
CA2 P00918 7/20 0.56
CA9 Q16790 7/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL826595 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL5376391 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL36572 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL9841217 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL410686 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL59420 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL21981206 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL20547409 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL22943835 1.00 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 664199 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9976147-B2 STAT3 inhibitors and uses thereof CITY OF HOPE (US) 2018-05-22 US claimed
WO-2018089472-A1 METHODS AND COMPOSITIONS USEFUL IN DETECTING PROTEINS BEATTY KIMBERLY (US) 2018-05-17 WO claimed
US-20180135045-A1 High Throughput Discovery of New Genes From Complex Mixtures of Environmental Microbes AgBiome, Inc. (US) 2018-05-17 US claimed
WO-2018089860-A1 METHODS FOR PROCESSING NUCLEIC ACID SAMPLES 2D GENOMICS INC. (US) 2018-05-17 WO claimed
US-20180135099-A1 NANOREPORTERS AND METHODS OF MANUFACTURING AND USE THEREOF NANOSTRING TECHNOLOGIES, INC. 2018-05-17 US claimed
US-20180134689-A1 BENZOCYANINE COMPOUNDS DYOMICS GMBH (DE) 2018-05-17 US claimed
US-20180134549-A1 MICRORNA INITIATED DNAZYME MOTOR OPERATING IN LIVING CELLS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2018-05-17 US claimed
US-20180136233-A1 PATHWAY SPECIFIC ASSAYS FOR PREDICTING IRRITABLE BOWEL SYNDROME DIAGNOSIS NESTEC S.A. (CH) 2018-05-17 US claimed
US-20180136217-A1 APTAMER SPECIFIC TO OVARIAN CANCER AND DETECTION METHOD FOR OVARIAN CANCER NATIONAL TSING HUA UNIVERSITY (TW) 2018-05-17 US claimed
US-20180136231-A1 Method, Array and Use for Determining the Presence of Pancreatic Cancer IMMUNOVIA AB (SE) 2018-05-17 US claimed
US-4081328-A HEAT RESISTANCE STANFORD RESEARCH INSTITUTE (US) 1978-03-28 US claimed
US-4072571-A Klebsiella pneumoniae and Enterobacter broth MCDONNELL DOUGLAS CORPORATION (US) 1978-02-07 US claimed
US-4058122-A Osmotic system with laminated wall formed of different materials ALZA CORPORATION (US) 1977-11-15 US claimed
US-4049494-A Vaccine production process THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1977-09-20 US claimed
US-4044020-A Process for preparing biotin SYNTEX (U.S.A.) INC. (US) 1977-08-23 US claimed
US-4042733-A Forming solid, adhesive-free composite of membrane filters and cellulosic cardboard BOEHRINGER INGELHEIM GMBH (DT) 1977-08-16 US claimed
US-4028184-A CULTURING CORYNEBACTERIUM, ARTHROBACTER, MICROBACTERIUM KIKKOMAN SHOYU CO., LTD. (JA) 1977-06-07 US claimed
US-3971701-A FATTY ACID, ESTER OR N-ACYLAMINO ACID SURFACTANT AJINOMOTO CO., INC. (JA) 1976-07-27 US claimed
US-3960884-A Method of preparing racemic biotin ZAVYALOV SERGEI IVANOVICH 1976-06-01 US claimed
US-3946115-A GRINDING, EXTRUSION RALSTON PURINA COMPANY (US) 1976-03-23 US claimed