Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424305 | 0.78 | KDM4E (0.65) | KDM4EF13A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8763140 | 0.73 | ACACB (0.43) | SMN1; SMN2RAB9ANPC1TSHRLMNA | |
| SCHEMBL8671157 | 0.73 | KDM4E (0.53) | KDM4EF13A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3055735 | 0.72 | MTNR1A (0.55) | MTNR1AMTNR1BANPEP | |
| SCHEMBL3039933 | 0.72 | MTNR1A (0.55) | MTNR1AMTNR1BANPEP | |
| SCHEMBL14795607 | 0.71 | LOXL2 (0.45) | SMN1; SMN2RAB9ANPC1HDAC2HDAC8 | |
| SCHEMBL18317154 | 0.69 | HDAC2 (0.58) | KDM4ESMN1; SMN2RAB9ANPC1HDAC2 | |
| Hydrochloric Acid SCHEMBL7204871 | 0.69 | ERAP2 (0.51) | SMN1; SMN2RAB9ALMNAERAP2ERAP1 | |
| Hydrochloric Acid SCHEMBL27556867 | 0.69 | ERAP2 (0.51) | SMN1; SMN2RAB9ALMNAERAP2ERAP1 | |
| SCHEMBL48578 | 0.68 | HTT (0.64) | SMN1; SMN2RAB9AHDAC6TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |