Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530395 | 0.75 | ALB (0.46) | ACACBTSHRLMNAMAPTALDH1A1 | |
| SCHEMBL8530388 | 0.75 | ALB (0.46) | ACACBTSHRLMNAMAPTALDH1A1 | |
| SCHEMBL8530392 | 0.75 | ALB (0.46) | ACACBTSHRLMNAMAPTALDH1A1 | |
| SCHEMBL8763145 | 0.73 | KDM4E (0.42) | TSHRLMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL13645720 | 0.73 | KMT2A (0.59) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17783704 | 0.72 | ROCK2 (0.44) | ACACBTSHRALDH1A1ACACACYP19A1 | |
| SCHEMBL14795607 | 0.72 | LOXL2 (0.45) | ALDH1A1CYP19A1MMP12MMP13NPC1 | |
| SCHEMBL8121443 | 0.71 | NAMPT (0.45) | ACACBTSHRLMNAMAPTMAPK1 | |
| Hydrazine SCHEMBL2567860 | 0.71 | LOXL2 (0.48) | LMNAMAPTMAPK1ALDH1A1CYP19A1 | |
| SCHEMBL18110390 | 0.70 | MMP13 (0.42) | ACACBTSHRLMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |