SCHEMBL8763285

SCHEMBL8763285

CC[Si](NC=O)(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADH1B P00325 1/20 0.38
ADH1C P00326 1/20 0.38
ADH1A P07327 1/20 0.38
ADH7 P40394 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
TAAR1 Q96RJ0 1/20 0.36
EPHX1 P07099 1/20 0.34
MAPT P10636 1/20 0.34
RECQL P46063 1/20 0.32
PSIP1 O75475 1/20 0.31
TP53 P04637 1/20 0.31
CYP2A6 P11509 1/20 0.31
MTNR1A P48039 1/20 0.31
MTNR1B P49286 1/20 0.31
KEAP1 Q14145 1/20 0.30
HTT P42858 1/20 0.30
TLR8 Q9NR97 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8763441 0.83 TP53 (0.31) ALDH1A1MAPTRECQLTP53
SCHEMBL14898478 0.75 ESR1 (0.33) MAPTTP53
SCHEMBL8593176 0.71 KMT2A (0.36) ALDH1A1MEN1KMT2AMAPTRECQL
SCHEMBL8763125 0.70 ALDH1A1 (0.44) ADH1BADH1CADH1AADH7ALDH1A1
SCHEMBL988676 0.66 NR1H2 (0.43) ALDH1A1MAPTPSIP1TP53
SCHEMBL2483998 0.66 TP53 (0.38) ALDH1A1MAPTPSIP1TP53
SCHEMBL3971800 0.66 MAPT (0.39) ALDH1A1MAPTPSIP1TP53
SCHEMBL20792266 0.64 ALDH1A1 (0.42) ADH1BADH1CADH1AADH7ALDH1A1
SCHEMBL2444645 0.64 ESR1 (0.56) ALDH1A1MAPTPSIP1TP53
SCHEMBL3889977 0.64 TP53 (0.41) ALDH1A1TAAR1MAPTPSIP1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349195-B1 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC (US) 1997-05-21 EP disclosed
US-5629394-A ENDCAPPING ADDITION POLYMERS WITH NITROGEN FUNCTIONAL GROUPS WHICH CAN BE FURTHER DERIVATIZED EXXON CHEMICAL PATENTS INC (US) 1997-05-13 US disclosed
US-5444135-A Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously EXXON CHEMICAL PATENTS INC. (US) 1995-08-22 US disclosed
US-5336745-A Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators EXXON CHEMICAL PATENTS INC. (US) 1994-08-09 US disclosed
US-5032653-A Catalysts EXXON CHEMICAL PATENTS, INC. (US) 1991-07-16 US disclosed
EP-0349195-A2 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC. (US) 1990-01-03 EP disclosed