Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 4/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785239 | 0.86 | MAPT (0.36) | MAPTPOLBHTR2AHTR2CHTR2B | |
| SCHEMBL785025 | 0.86 | MAPT (0.36) | MAPTPOLBHTR2AHTR2CHTR2B | |
| SCHEMBL784912 | 0.83 | MAPK14 (0.40) | MAPTPOLBALDH1A1 | |
| SCHEMBL784913 | 0.83 | MAPK14 (0.40) | MAPTPOLBALDH1A1 | |
| SCHEMBL877902 | 0.78 | MTNR1B (0.40) | MAPTPOLBHTR2AHTR2CHTR2B | |
| SCHEMBL785431 | 0.74 | FABP4 (0.40) | MAPTPOLBHTR2AHTR2CHTR2B | |
| SCHEMBL784719 | 0.74 | FABP4 (0.40) | MAPTPOLBHTR2AHTR2CHTR2B | |
| SCHEMBL785419 | 0.72 | BDKRB1 (0.39) | POLBPARP1 | |
| SCHEMBL785374 | 0.72 | MAPT (0.38) | MAPTPOLBALDH1A1 | |
| SCHEMBL785549 | 0.71 | MAPT (0.41) | MAPTPOLBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |