Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762465 | 0.97 | ALDH1A1 (0.46) | ALDH1A1HSD17B10ADRA2AADRA2BADRA2C | |
| SCHEMBL8763532 | 0.94 | ALDH1A1 (0.48) | ALDH1A1HSD17B10ADRA2AADRA2BADRA2C | |
| SCHEMBL3758835 | 0.78 | HSD17B10 (0.51) | ALDH1A1HSD17B10ADRA2AKMT2AMEN1 | |
| SCHEMBL3758360 | 0.75 | HSD17B10 (0.47) | ALDH1A1HSD17B10ADRA2AKMT2AMEN1 | |
| SCHEMBL10977557 | 0.74 | HTR1D (0.44) | ALDH1A1HSD17B10ADRA2AADRA2BADRA2C | |
| SCHEMBL10979564 | 0.74 | ALDH1A1 (0.42) | ALDH1A1ADRA2AADRA2BADRA2CKMT2A | |
| SCHEMBL8764346 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HSD17B10ADRA2AADRA2BADRA2C | |
| SCHEMBL9616494 | 0.72 | HTT (0.49) | ALDH1A1ADRA2AADRA2BADRA2CKMT2A | |
| SCHEMBL10994971 | 0.72 | GPR35 (0.40) | ALDH1A1GPR35KMT2AMEN1MAPT | |
| SCHEMBL11175973 | 0.71 | HSD17B10 (0.50) | ALDH1A1HSD17B10ADRA2AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684156-A | Process for preparation of clonidine derivatives | ALCON RESEARCH, LTD. | 1997-11-04 | — | — | US | disclosed |
| EP-0693055-B1 | NOVEL PROCESS FOR PREPARATION OF CLONIDINE DERIVATIVES | ALCON LAB INC (US) | 1997-05-21 | — | — | EP | disclosed |