Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31483704 | 0.81 | GAA (0.41) | GAATSHRPARP10PARP11MAOB | |
| SCHEMBL20836473 | 0.81 | GAA (0.41) | GAATSHRPARP10PARP11MAOB | |
| SCHEMBL6965670 | 0.80 | CCNT1 (0.45) | ACHEKDM4ECCNT1CDK9GAA | |
| SCHEMBL26938715 | 0.73 | QDPR (0.52) | ACHEKDM4ECCNT1CDK9KMT2A | |
| SCHEMBL18330519 | 0.73 | SUV39H2 (0.44) | ACHECCNT1CDK9ALDH1A1CYP3A4 | |
| SCHEMBL6602348 | 0.72 | KDM4E (0.44) | KDM4ECCNT1CDK9GAAALDH1A1 | |
| SCHEMBL9938324 | 0.72 | ACHE (0.68) | ACHEPOLBMCOLN3USP2KMT2A | |
| SCHEMBL20500724 | 0.72 | PTGS2 (0.45) | KDM4EPOLBCCNT1CDK9KMT2A | |
| SCHEMBL10131895 | 0.71 | GAA (0.38) | ACHEGAAKMT2AALDH1A1HPGD | |
| SCHEMBL8763677 | 0.70 | POLL (0.38) | KDM4ECCNT1CDK9GAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677046-B1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-07-09 | — | — | EP | disclosed |
| US-5622951-A | Piperazine derivatives as 5-HT antagonists | JOHN WYETH & BROTHER LTD. (GB) | 1997-04-22 | — | — | US | disclosed |
| EP-0677046-A1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS. | WYETH JOHN & BROTHER LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994015928-A1 | PIPERAZINE DERIVATIVES AS 5-HT ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-07-21 | — | — | WO | disclosed |