Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688253 | 0.90 | MAOA (0.57) | PBRM1BRD4HRH3MAOBMAOA | |
| SCHEMBL27819611 | 0.88 | BRD4 (0.52) | PBRM1BRD4HRH3MAOBMAOA | |
| SCHEMBL10503926 | 0.81 | PBRM1 (0.39) | PBRM1BRD4HRH3MAOBMAOA | |
| SCHEMBL3888850 | 0.81 | RAB9A (0.53) | PBRM1BRD4HRH3 | |
| Acetic Acid SCHEMBL6934641 | 0.80 | MAOB (0.51) | PBRM1BRD4HRH3MAOBMAPK14 | |
| SCHEMBL31638292 | 0.79 | BRD4 (0.50) | PBRM1BRD4HRH3MAOBMAOA | |
| SCHEMBL10503520 | 0.79 | PBRM1 (0.37) | PBRM1BRD4HRH3MAOBMAOA | |
| SCHEMBL8318501 | 0.79 | MAOA (0.53) | BRD4HRH3MAOBMAOAMAPK14 | |
| SCHEMBL10444174 | 0.78 | KDM4E (0.45) | GRM5MAPK14ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29243215 | 0.78 | MAOA (0.55) | PBRM1BRD4HRH3MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |