Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.43 |
| ▸ | EYA3 | Q99504 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | EYA2 | O00167 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618947 | 0.90 | ASF1A (0.42) | NR1H4SLC22A12EYA3THRBTHRA | |
| SCHEMBL8624542 | 0.83 | ASF1A (0.44) | NR1H4SLC22A12THRBALDH1A1CYP1A2 | |
| SCHEMBL8763724 | 0.81 | THRA (0.49) | SLC22A12THRBTHRAMEN1ALDH1A1 | |
| SCHEMBL8618658 | 0.77 | THRA (0.53) | NR1H4EYA3THRBTHRATTR | |
| SCHEMBL8624230 | 0.73 | THRA (0.48) | THRBTHRAMEN1POLBMAPT | |
| SCHEMBL8617561 | 0.72 | THRB (0.47) | THRBTHRAALDH1A1LMNACYP1A2 | |
| SCHEMBL6344860 | 0.71 | NR1H4 (0.61) | NR1H4SLC22A12EYA3THRBTHRA | |
| SCHEMBL8618728 | 0.70 | MAPT (0.39) | SLC22A12THRBALDH1A1CYP1A2MAPT | |
| SCHEMBL8619949 | 0.70 | THRA (0.45) | THRBTHRAMEN1LMNAMAPT | |
| SCHEMBL8618731 | 0.70 | MAPT (0.41) | SLC22A12THRBCYP2C19ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |