Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617561 | 0.91 | THRB (0.47) | THRATHRBKDM4EALDH1A1MAPT | |
| SCHEMBL8617540 | 0.82 | THRA (0.49) | THRATHRBALDH1A1SLC22A12TP53 | |
| SCHEMBL8764634 | 0.81 | NR1H4 (0.45) | THRATHRBALDH1A1CYP2C9SLC22A12 | |
| SCHEMBL8624230 | 0.81 | THRA (0.48) | THRATHRBMAPTSMN1; SMN2TP53 | |
| SCHEMBL8624542 | 0.80 | ASF1A (0.44) | THRBKDM4EALDH1A1SLC22A12MAPT | |
| SCHEMBL8622615 | 0.78 | MAPT (0.40) | THRBKDM4EALDH1A1SLC22A12MAPT | |
| SCHEMBL8619949 | 0.78 | THRA (0.45) | THRATHRBMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8617962 | 0.78 | THRA (0.52) | THRATHRBALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL8622612 | 0.78 | THRB (0.37) | THRATHRBKDM4EALDH1A1SLC22A12 | |
| SCHEMBL8622465 | 0.77 | THRA (0.66) | THRATHRBABCB1SIRT3KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |