Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876773 | 0.83 | LRRK2 (0.42) | KMT2ALRRK2 | |
| SCHEMBL877737 | 0.80 | MMP2 (0.46) | MAPTKMT2AALDH1A1MMP1MMP2 | |
| SCHEMBL873743 | 0.80 | PHGDH (0.48) | MAPTKMT2AALDH1A1HPGDHSP90AA1 | |
| SCHEMBL882660 | 0.80 | SLC6A3 (0.45) | MAPTKMT2AALDH1A1HPGDMMP1 | |
| SCHEMBL882712 | 0.70 | HDAC6 (0.47) | — | |
| SCHEMBL21961348 | 0.70 | BRD4 (0.46) | ALDH1A1 | |
| SCHEMBL30583813 | 0.70 | NPC1 (0.57) | MAPTKMT2AALDH1A1EPHX1MMP2 | |
| SCHEMBL30583812 | 0.70 | NPC1 (0.57) | MAPTKMT2AALDH1A1EPHX1MMP2 | |
| SCHEMBL28975685 | 0.70 | NPC1 (0.57) | MAPTKMT2AALDH1A1EPHX1MMP2 | |
| SCHEMBL874709 | 0.69 | CA12 (0.43) | MAPTKMT2AALDH1A1DRD4KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |