Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876507 | 0.83 | MAPT (0.46) | LRRK2KMT2A | |
| SCHEMBL874150 | 0.78 | HDAC6 (0.48) | ACVR1BRD4KDM4EHTTMAPK14 | |
| SCHEMBL29260996 | 0.72 | TUBB4A (0.55) | — | |
| SCHEMBL10065075 | 0.72 | LRRK2 (0.34) | LRRK2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3633642 | 0.72 | RAB9A (0.72) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL21960833 | 0.69 | BRD4 (0.49) | BRD4KDM4EHTTSMYD3 | |
| SCHEMBL3442327 | 0.66 | RAB9A (0.62) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL30583805 | 0.66 | RAB9A (0.62) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL874498 | 0.66 | ACKR3 (0.43) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL12591849 | 0.65 | RAB9A (0.66) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |