SCHEMBL8765310

SCHEMBL8765310

Nc1ccccc1Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 11/20 0.67
▸ KMT2A Q03164 7/20 0.67
▸ MEN1 O00255 6/20 0.67
▸ GFER P55789 2/20 0.67
▸ HPGD P15428 2/20 0.62
▸ L3MBTL1 Q9Y468 2/20 0.62
▸ ALOX12 P18054 1/20 0.62
▸ KDM4E B2RXH2 5/20 0.59
▸ TP53 P04637 1/20 0.59
▸ APP P05067 1/20 0.59
▸ ALOX15 P16050 1/20 0.59
▸ SNCA P37840 1/20 0.59
▸ BLM P54132 1/20 0.59
▸ SMN1; SMN2 Q16637 1/20 0.59
▸ HSD17B10 Q99714 1/20 0.59
▸ TDP1 Q9NUW8 5/20 0.59
▸ GAA P10253 4/20 0.59
▸ ATM Q13315 1/20 0.59
▸ ALDH1A1 P00352 4/20 0.58
▸ LMNA P02545 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13265903 0.83 RORC (0.62) MAPTKMT2AMEN1GFERSMN1; SMN2
SCHEMBL27927838 0.81 MAPT (0.79) MAPTKMT2AMEN1GFERHPGD
SCHEMBL4607773 0.81 MAPT (0.86) MAPTKMT2AMEN1GFERHPGD
SCHEMBL13862153 0.81 TDP1 (0.66) MAPTKMT2AMEN1GFERHPGD
SCHEMBL5718635 0.81 MAPK1 (0.77) MAPTKMT2AMEN1GFERHPGD
SCHEMBL6582107 0.80 MAPT (1.00) MAPTKMT2AMEN1GFERHPGD
SCHEMBL11025851 0.79 L3MBTL1 (0.62) MAPTKMT2AMEN1GFERHPGD
SCHEMBL11408774 0.79 L3MBTL1 (0.62) MAPTKMT2AMEN1GFERHPGD
SCHEMBL30499873 0.79 L3MBTL1 (0.62) MAPTKMT2AMEN1GFERHPGD
SCHEMBL23243062 0.78 MAPT (0.73) MAPTKMT2AMEN1GFERHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0567379-B1 Photochemically crosslinked material for non-linear optical application THOMSON CSF (FR) 1997-07-23 — — EP disclosed
US-5460907-A Polymer, optical chromophore, charge transport agent; diffraction efficiency; waveguides INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1995-10-24 — — US disclosed
EP-0477666-B1 Cross-linked epoxy-resins with non-linear optical properties SIEMENS AG (DE) 1995-06-28 — — EP disclosed
US-5420172-A Cross-linked epoxy resins having non-linear optical properties SIEMENS AKTIENGESELLSCHAFT (DE) 1995-05-30 — — US disclosed
EP-0477665-B1 Cross-linked epoxy resins with non-linear optical properties SIEMENS AG (DE) 1994-11-23 — — EP disclosed
EP-0593866-A1 Crosslinked epoxy resins having nonlinear optical properties SIEMENS AKTIENGESELLSCHAFT (DE) 1994-04-27 — — EP disclosed
EP-0567379-A1 Photochemically crosslinked material for non-linear optical application THOMSON-CSF (FR) 1993-10-27 — — EP disclosed
US-5218074-A CROSS-LINKED EPOXY RESINS WITH NON-LINEAR OPTICAL PROPERTIES SIEMENS AKTIENGESELLSCHAFT (DE) 1993-06-08 — — US disclosed
US-5187237-A Addition copolymers of an epoxy-containing acrylic ester or amide and an acrylic ester or amide having a nonlinear optical group: glass transition temperature SIEMENS AKTIENGESELLSCHAFT (DE) 1993-02-16 — — US disclosed
EP-0482779-A2 Photorefractive material International Business Machines Corporation (US) 1992-04-29 — — EP disclosed
EP-0477665-A1 Cross-linked epoxy resins with non-linear optical properties SIEMENS AKTIENGESELLSCHAFT (DE) 1992-04-01 — — EP disclosed
EP-0477667-A2 Cured epoxy resins having nonlinear optical properties SIEMENS AKTIENGESELLSCHAFT (DE) 1992-04-01 — — EP disclosed
EP-0477666-A1 Cross-linked epoxy-resins with non-linear optical properties SIEMENS AKTIENGESELLSCHAFT (DE) 1992-04-01 — — EP disclosed
US-5064264-A Optical waveguides INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1991-11-12 — — US disclosed
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