SCHEMBL8765442

SCHEMBL8765442

Clc1cc(Cl)c2cccc3c2c1C=C3

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.36
CYP2A6 P11509 3/20 0.36
NR4A2 P43354 1/20 0.33
AHR P35869 3/20 0.33
TYMS P04818 1/20 0.32
MEN1 O00255 2/20 0.31
MAPT P10636 2/20 0.31
KMT2A Q03164 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
KDM4E B2RXH2 1/20 0.31
ALOX15B O15296 1/20 0.31
NR1I2 O75469 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
HSP90AA1 P07900 1/20 0.31
CYP3A4 P08684 1/20 0.31
HTR1A P08908 1/20 0.31
ALOX5 P09917 1/20 0.31
MMP9 P14780 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3408215 0.74 CYP1A2 (0.48) CYP1A2CYP2A6NR4A2TYMSMEN1
SCHEMBL8764631 0.73 CYP2A6 (0.37) CYP1A2CYP2A6NR4A2AHR
SCHEMBL8764916 0.72 CYP1A2 (0.35) CYP1A2CYP2A6TYMS
SCHEMBL20356028 0.70 CYP1A2 (0.48) CYP1A2CYP2A6NR4A2AHRTYMS
SCHEMBL5039138 0.69 ALDH1A1 (0.40) CYP1A2CYP2A6MEN1KMT2AKDM4E
SCHEMBL8764547 0.68 HSP90AA1 (0.31) MEN1MAPTKMT2ASMN1; SMN2KDM4E
SCHEMBL4225366 0.67 CYP2A6 (0.40) CYP1A2CYP2A6AHRMAPTALDH1A1
SCHEMBL10549323 0.67 TYMS (0.38) CYP1A2CYP2A6NR4A2TYMSMEN1
SCHEMBL22129898 0.66 CDC25A (0.35) CYP1A2CYP2A6AHRTYMSMEN1
SCHEMBL3754754 0.65 MAPT (0.47) CYP1A2CYP2A6TYMSMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0505972-B1 Process for producing styrenic copolymer IDEMITSU KOSAN CO (JP) 1997-06-11 EP disclosed
EP-0505972-A2 Process for producing styrenic copolymer IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-09-30 EP disclosed