Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765062 | 0.90 | PTGS2 (0.49) | PTGS2 | |
| SCHEMBL8765684 | 0.90 | HSD11B1 (0.46) | PTGS2ALOX5 | |
| SCHEMBL8764443 | 0.88 | PTGS2 (0.46) | PTGS2 | |
| SCHEMBL8765496 | 0.84 | PTGS2 (0.49) | PTGS2 | |
| SCHEMBL8764433 | 0.83 | PTGS2 (0.44) | PTGS2ALOX5 | |
| SCHEMBL8672399 | 0.83 | PTGS2 (0.51) | PTGS2ALOX5 | |
| SCHEMBL8765159 | 0.83 | PTGS2 (0.44) | PTGS2ALOX5 | |
| SCHEMBL8765498 | 0.82 | PTGS2 (0.51) | PTGS2 | |
| SCHEMBL8765892 | 0.80 | PTGS2 (0.46) | PTGS2ALOX5 | |
| Dimethylamine SCHEMBL8765691 | 0.80 | PTGS2 (0.48) | PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |