Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973534 | 0.81 | CA12 (0.56) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL8766495 | 0.76 | ESR1 (0.37) | CA12CA1CA2CA9ERBB2 | |
| SCHEMBL8766175 | 0.72 | CA12 (0.57) | CA12CA1CA2CA9NPSR1 | |
| SCHEMBL8767390 | 0.71 | ESR1 (0.40) | ERBB2GRM1GRM4ESR1ESR2 | |
| SCHEMBL14560075 | 0.71 | ERBB2 (0.51) | ERBB2GRM1GRM4ESR1ESR2 | |
| SCHEMBL7119145 | 0.68 | HMGCR (0.46) | L3MBTL1NPSR1HMGCRLMNAMAPT | |
| SCHEMBL11787416 | 0.67 | GRM1 (0.53) | CA12CA1CA9ERBB2GRM1 | |
| SCHEMBL5903417 | 0.67 | ESR1 (0.61) | ERBB2GRM1GRM4ESR1ESR2 | |
| SCHEMBL9403099 | 0.64 | HMGCR (0.45) | CA12CA1CA2CA9NPSR1 | |
| SCHEMBL13222267 | 0.64 | ERBB2 (0.51) | ERBB2GRM1GRM4ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |