Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.57 |
| ▸ | CA1 | P00915 | 6/20 | 0.57 |
| ▸ | CA2 | P00918 | 6/20 | 0.57 |
| ▸ | CA9 | Q16790 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973534 | 0.88 | CA12 (0.56) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL7119145 | 0.80 | HMGCR (0.46) | GAATDP1HMGCRKDM4EPTPN2 | |
| SCHEMBL9403099 | 0.77 | HMGCR (0.45) | CA12CA1CA2CA9GAA | |
| SCHEMBL8011719 | 0.72 | HMGCR (0.51) | GAAEPHX2HMGCRKDM4ENPSR1 | |
| SCHEMBL8766182 | 0.72 | CA12 (0.39) | CA12CA1CA2CA9GAA | |
| SCHEMBL8766613 | 0.71 | HMGCR (0.49) | GAAHMGCRKDM4EPOLBNPSR1 | |
| SCHEMBL11512432 | 0.71 | HMGCR (0.46) | GAAEPHX2HMGCR | |
| SCHEMBL9418530 | 0.71 | HMGCR (0.60) | CA1CA2GAAHMGCRPOLB | |
| SCHEMBL8015604 | 0.70 | GAA (0.48) | GAAHMGCRNPSR1 | |
| SCHEMBL8003353 | 0.70 | HMGCR (0.47) | GAATDP1HMGCRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |