Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 10/20 | 0.56 |
| ▸ | CA1 | P00915 | 10/20 | 0.56 |
| ▸ | CA2 | P00918 | 10/20 | 0.56 |
| ▸ | CA9 | Q16790 | 10/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766175 | 0.88 | CA12 (0.57) | CA12CA1CA2CA9HMGCR | |
| SCHEMBL8766182 | 0.81 | CA12 (0.39) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL7119145 | 0.81 | HMGCR (0.46) | L3MBTL1HMGCRMAPTKDM4EPTPN2 | |
| SCHEMBL9403099 | 0.78 | HMGCR (0.45) | CA12CA1CA2CA9HMGCR | |
| SCHEMBL8011719 | 0.73 | HMGCR (0.51) | HMGCRKDM4EEPHX2 | |
| SCHEMBL11512432 | 0.72 | HMGCR (0.46) | HMGCRMAPTEPHX2 | |
| SCHEMBL8766613 | 0.72 | HMGCR (0.49) | HMGCRMAPTKDM4EPOLB | |
| SCHEMBL9418530 | 0.71 | HMGCR (0.60) | CA1CA2L3MBTL1HMGCRMAPT | |
| SCHEMBL8015604 | 0.71 | GAA (0.48) | HMGCRMAPT | |
| SCHEMBL8003353 | 0.70 | HMGCR (0.47) | L3MBTL1HMGCRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703239-A1 | Aminomethylphosphonic and aminomethylphosphinic acids derivatives and their use in the treatment of degenerative articular diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-03-27 | — | — | EP | disclosed |