SCHEMBL876644

SCHEMBL876644

N#C/C(N)=C\c1ccc(O)c(O)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 12/20 0.67
KDM4E B2RXH2 7/20 0.67
MEN1 O00255 7/20 0.67
ALDH1A1 P00352 7/20 0.67
KMT2A Q03164 7/20 0.67
HPGD P15428 6/20 0.67
MAPT P10636 5/20 0.67
HSD17B10 Q99714 5/20 0.67
TP53 P04637 4/20 0.67
CYP1A2 P05177 4/20 0.67
BLM P54132 4/20 0.67
ALOX15 P16050 4/20 0.67
ALOX12 P18054 4/20 0.67
SMN1; SMN2 Q16637 4/20 0.67
CYP3A4 P08684 3/20 0.67
MAPK1 P28482 3/20 0.67
PMP22 Q01453 3/20 0.67
HIF1A Q16665 3/20 0.67
L3MBTL1 Q9Y468 3/20 0.67
CYP2D6 P10635 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL876645 1.00 EGFR (0.67) EGFRKDM4EMEN1ALDH1A1KMT2A
SCHEMBL13928220 0.80 EGFR (0.64) EGFRKDM4EMEN1ALDH1A1KMT2A
Tyrphostin 23 SCHEMBL29360636 0.80 EGFR (1.00) EGFRKDM4EMEN1ALDH1A1KMT2A
Tyrphostin 23 SCHEMBL241922 0.80 EGFR (1.00) EGFRKDM4EMEN1ALDH1A1KMT2A
SCHEMBL13060220 0.80 EGFR (0.77) EGFRKDM4EMEN1ALDH1A1KMT2A
Tyrphostin 47 SCHEMBL1704818 0.79 EGFR (1.00) EGFRKDM4EMEN1ALDH1A1KMT2A
Tyrphostin 47 SCHEMBL5802735 0.79 EGFR (1.00) EGFRKDM4EMEN1ALDH1A1KMT2A
SCHEMBL6285299 0.79 EGFR (1.00) EGFRKDM4EMEN1ALDH1A1KMT2A
Tyrphostin 47 SCHEMBL5802738 0.79 EGFR (1.00) EGFRKDM4EMEN1ALDH1A1KMT2A
SCHEMBL7908162 0.79 EGFR (0.71) EGFRKDM4EMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0403238-A2 Cosmetic composition UNILEVER PLC (GB) 1990-12-19 EP claimed
EP-4340807-A1 HAIR COLOR COMPOSITIONS FOR MITIGATING COLOR LOSS Lubrizol Advanced Materials, Inc. (US) 2024-03-27 EP disclosed
EP-3773458-A1 HAIR MODIFICATION COMPOSITION AND METHOD THEREFOR Lubrizol Advanced Materials, Inc. (US) 2021-02-17 EP disclosed
US-10758490-B2 Nanocapsules containing microemulsions LIPOTEC, S.A. (ES) 2020-09-01 US disclosed
WO-2019200027-A1 HAIR MODIFICATION COMPOSITION AND METHOD THEREFOR LUBRIZOL ADVANCED MATERIALS, INC. (US) 2019-10-17 WO disclosed
EP-2618926-B1 NANOCAPSULES CONTAINING MICROEMULSIONS LIPOTEC SA (ES) 2019-05-08 EP disclosed
US-20180311358-A1 THERMOFORMABLE DUAL NETWORK HYDROGEL COMPOSITIONS LUBRIZOL ADVANCED MATERIALS, INC. 2018-11-01 US disclosed
EP-3371238-A1 THERMOFORMABLE DUAL NETWORK HYDROGEL COMPOSITIONS Lubrizol Advanced Materials, Inc. (US) 2018-09-12 EP disclosed
EP-2536815-B1 USE OF LIPOSOMES FOR THE TREATMENT OF TEXTILE MATERIALS LIPOTEC SA (ES) 2018-07-11 EP disclosed
EP-3272398-A1 LIPID NANOPARTICLE CAPSULES Lipotec S.A. (ES) 2018-01-24 EP disclosed
EP-0572167-B1 Cosmetic composition UNILEVER PLC (GB) 1996-10-09 EP disclosed
US-5559092-A HAIR GROWTH, GLUTAMINE DIPEPTIDE CHESEBROUGH-POND'S USA CO. DIVISION OF CONOPCO, INC. (US) 1996-09-24 US disclosed
EP-0517371-B1 Hair growth composition containing citric acid esters UNILEVER PLC (GB) 1996-01-10 EP disclosed
WO-1995024896-A2 USE OF ANTAGONISTS OF EGF OR TGF-ALPHA FOR THE TREATMENT AND PROPHYLAXIS OF ACNE UNILEVER PLC (GB) 1995-09-21 WO disclosed
US-5328914-A Use of pyrimidine 3-oxide derivatives for slowing down hair loss and topical compositions used L'OREAL (FR) 1994-07-12 US disclosed
EP-0580409-A2 Cosmetic composition containing DOPA derivatives UNILEVER PLC (GB) 1994-01-26 EP disclosed
EP-0572167-A1 Cosmestic composition UNILEVER PLC (GB) 1993-12-01 EP disclosed
EP-0571198-A1 Cosmetic composition containing hair-growth promoter UNILEVER PLC (GB) 1993-11-24 EP disclosed
EP-0517371-A2 Hair growth composition containing citric acid esters UNILEVER PLC (GB) 1992-12-09 EP disclosed
EP-0490581-A1 Cosmetic composition UNILEVER PLC (GB) 1992-06-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180311358-A1 THERMOFORMABLE DUAL NETWORK HYDROGEL COMPOSITIONS HSF1, DUOX2, HSPA2 EGFR 1509/4885KDM4E 4554/4885MEN1 4445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.