DUOX2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2027831	1.00	1/20
SCHEMBL29368383	1.00	1/20
SCHEMBL4923550	0.80	1/20
SCHEMBL4920436	0.78	1/20
SCHEMBL4928536	0.73	1/20
SCHEMBL4920666	0.71	1/20
SCHEMBL15313075	0.69	1/20
SCHEMBL4920220	0.69	1/20
SCHEMBL4928611	0.68	1/20
SCHEMBL17210872	0.67	1/20
SCHEMBL4937076	0.66	1/20
SCHEMBL29490371	0.66	1/20
SCHEMBL16560732	0.63	1/20
SCHEMBL4941814	0.60	1/20
SCHEMBL4918509	0.57	1/20
SCHEMBL4930461	0.57	1/20
SCHEMBL23585073	0.47	1/20

Clinical trials — most relevant to DUOX2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Randomized Controlled Trial of Silymarin in Asthma	PHASE2/PHASE3	WITHDRAWN
Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers	PHASE3	COMPLETED
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis	PHASE2/PHASE3	UNKNOWN
Defibrotide in COVID-19 Pneumonia	PHASE2	COMPLETED
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing.	PHASE1/PHASE2	COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE	PHASE2	UNKNOWN
Effects of Febuxostat for Lowering Uric Acid in NAFLD Patients With Gout	PHASE2	UNKNOWN
NOX-100 for Preventing Hypotension During Hemodialysis	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers	PHASE1	COMPLETED
Effect of Simvastatin on CF Airway Inflammation	PHASE1	COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Endometriosis and Microvascular Dysfunction: Role of Inflammation	EARLY_PHASE1	RECRUITING
Mechanisms of Action of Acetaminophen	nan	COMPLETED
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings	nan	NOT_YET_RECRUITING
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19	nan	COMPLETED
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery	nan	COMPLETED
Impact of RIVP on GI Function in Patients Undergoing Surgical Repair for ATAAD	nan	UNKNOWN
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DUOX2 binder may also engage these)

Protein	Name	Similarity
Q9ES45	—	1.000	Q9ES45 →
Q8HZK3	—	1.000	Q8HZK3 →
Q9MZF4	—	1.000	Q9MZF4 →
Q8HZK2	—	1.000	Q8HZK2 →
Q8CIY2	—	1.000	Q8CIY2 →
DUOX1	Dual oxidase 1	0.995	landscape →
A2AQ92	—	0.994	A2AQ92 →
Q9VQH2	—	0.984	Q9VQH2 →
Q8CFX1	—	0.974	Q8CFX1 →
Q92179	—	0.972	Q92179 →
O95479	—	0.972	O95479 →
Q61139	—	0.971	Q61139 →
Q6PDS3	—	0.971	Q6PDS3 →
PCSK7	Proprotein convertase subtilisin/kexin type 7	0.971	landscape →
Q9BYX2	—	0.971	Q9BYX2 →
Q80XH4	—	0.971	Q80XH4 →
B2GUY2	—	0.970	B2GUY2 →
TYR	Tyrosinase	0.970	landscape →
Q8C0R7	—	0.970	Q8C0R7 →
B2RUP2	—	0.970	B2RUP2 →
Q5NDF0	—	0.969	Q5NDF0 →
Q5NDF1	—	0.969	Q5NDF1 →
Q8NAT1	—	0.969	Q8NAT1 →
Q8R4K8	—	0.969	Q8R4K8 →
F1ND48	—	0.969	F1ND48 →
Q8BYH7	—	0.969	Q8BYH7 →
Q66PG4	—	0.968	Q66PG4 →
RIOX2	Ribosomal oxygenase 2	0.968	landscape →
Q6L9W6	—	0.968	Q6L9W6 →
A7UA95	—	0.968	A7UA95 →