Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.46 |
| ▸ | RELA | Q04206 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766676 | 0.97 | RAB9A (0.50) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL8766342 | 0.92 | SMN1; SMN2 (0.54) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL9433608 | 0.90 | RAB9A (0.46) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL9434295 | 0.87 | NPC1 (0.41) | RAB9AL3MBTL1NPC1SMN1; SMN2NFKB1 | |
| SCHEMBL8766807 | 0.87 | RAB9A (0.39) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL9433261 | 0.87 | RAB9A (0.47) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL8766819 | 0.86 | RARB (0.43) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL8766681 | 0.83 | HSD17B10 (0.49) | MAPTTP53HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8766253 | 0.83 | RARB (0.38) | RAB9AMAPTL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL8767207 | 0.82 | HSD17B10 (0.51) | RAB9AMAPTSMN1; SMN2TP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543244-B1 | Fluoro substituted tolans and liquid crystal mixtures containing them | MERCK PATENT GMBH (DE) | 1997-08-20 | — | — | EP | disclosed |
| US-5372746-A | Fluoro-substituted tolane compounds and liquid crystalline mixtures containing same | HOFFMANN-LA ROCHE INC. (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0543244-A1 | Fluoro substituted tolans and liquid crystal mixtures containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1993-05-26 | — | — | EP | disclosed |