Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 16/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9180604 | 0.75 | PTGS1 (0.68) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL9457150 | 0.75 | SMPD3 (0.58) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL9179869 | 0.74 | PTGS1 (1.00) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL9185074 | 0.74 | PTGS1 (0.66) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL803157 | 0.73 | CA2 (1.00) | PTGS1PTGS2CA1CA2 | |
| SCHEMBL9312733 | 0.73 | PTGS1 (0.61) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL9180823 | 0.72 | PTGS1 (1.00) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL1927808 | 0.72 | PTGS1 (0.48) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL9503225 | 0.71 | PTGS1 (0.43) | PTGS1PTGS2CA1CA2ALOX5 | |
| SCHEMBL9731608 | 0.71 | HPN (0.49) | PTGS1PTGS2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371438-B1 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER LAMBERT CO (US) | 1995-08-30 | — | — | EP | claimed |
| US-5155122-A | Cyclooxygenase, lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1992-10-13 | — | — | US | claimed |
| EP-0371438-A2 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1990-06-06 | — | — | EP | claimed |
| JP-2270865-A | — | — | None | — | — | JP | disclosed |
| EP-0787130-A1 | DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996012710-A1 | DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-05-02 | — | — | WO | disclosed |
| EP-0371438-B1 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER LAMBERT CO (US) | 1995-08-30 | — | — | EP | disclosed |
| EP-0371438-B1 | 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents | WARNER LAMBERT CO (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5376670-A | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1994-12-27 | — | — | US | disclosed |
| US-5376670-A | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1994-12-27 | — | — | US | disclosed |
| US-5342958-A | Insecticides | SOLVAY DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1994-08-30 | — | — | US | disclosed |
| US-4166124-A | IMIDAZOLE OR PYRIMIDINE RINGS | U.S. PHILIPS CORPORATION (US) | 1979-08-28 | — | — | US | disclosed |
| US-4156007-A | INSECTICIDES | U.S. PHILIPS CORPORATION (US) | 1979-05-22 | — | — | US | disclosed |
| US-4110469-A | Insecticidal N-(2,6-dichlorobenzoyl)-N'-(4-cyanophenyl) urea | U.S. PHILIPS CORPORATION (US) | 1978-08-29 | — | — | US | disclosed |
| US-4070365-A | INSECTICIDES | U.S. PHILIPS CORPORATION (US) | 1978-01-24 | — | — | US | disclosed |
| US-4013717-A | BENZOYL PHENYL UREA DERIVATIVES HAVING INSECTICIDAL ACTIVITIES | U.S. PHILIPS CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |
| US-4010271-A | NOVEL PYRAZOLINE COMPOUNDS HAVING INSECTICIDAL ACTIVITY | U.S. PHILIPS CORPORATION (US) | 1977-03-01 | — | — | US | disclosed |
| US-3991073-A | Pyrazoline compounds having insecticidal activity | U.S. PHILIPS CORPORATION (US) | 1976-11-09 | — | — | US | disclosed |
| US-3989842-A | Certain substituted benzoyl urea insecticides | U.S. PHILIPS CORPORATION (US) | 1976-11-02 | — | — | US | disclosed |
| US-3933908-A | INSECTICIDE | U.S. PHILIPS CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |