Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8504318 | 0.99 | PLAU (0.38) | PLAUSLC9A1SCN5ASCN2ASLC9A2 | |
| Hydrochloric Acid SCHEMBL8503974 | 0.86 | S1PR1 (0.42) | PLAUSLC9A1SCN5ASCN2AHTT | |
| Hydrochloric Acid SCHEMBL8504098 | 0.84 | PLAU (0.36) | PLAUSLC9A1SCN5ASCN2ASLC9A2 | |
| SCHEMBL8768105 | 0.81 | HSP90AA1 (0.49) | PLAUF2PRSS1NR1H4HTT | |
| SCHEMBL20077881 | 0.81 | PLAU (0.38) | PLAUKLKB1F2PLGPLAT | |
| Hydrochloric Acid SCHEMBL8507099 | 0.80 | PLAU (0.37) | PLAUKLKB1F2PLGPLAT | |
| Hydrochloric Acid SCHEMBL8506619 | 0.80 | HSP90AA1 (0.48) | PLAUF2PRSS1NR1H4HTT | |
| SCHEMBL8768306 | 0.80 | HPGD (0.42) | PLAUSCN5ASCN2A | |
| Cariporide SCHEMBL39639 | 0.80 | SLC9A1 (0.61) | PLAUSLC9A1SCN5ASCN2ASLC9A2 | |
| Hydrochloric Acid SCHEMBL8503949 | 0.79 | HPGD (0.41) | PLAUSCN5ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |