Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8503949 | 0.99 | HPGD (0.41) | HPGDPLAUKDM4EMEN1KMT2A | |
| SCHEMBL6681402 | 0.81 | BCAT2 (0.57) | HPGDKDM4EMEN1KMT2ABCAT2 | |
| SCHEMBL8766934 | 0.80 | PLAU (0.39) | PLAUSCN5ASCN2A | |
| SCHEMBL25665748 | 0.80 | TAS1R3 (0.41) | PLAUSCN5ASCN2ATAS1R3TAS1R1 | |
| Hydrochloric Acid SCHEMBL8446579 | 0.80 | SCN5A (0.40) | PLAUMEN1KMT2ASCN5ASCN2A | |
| SCHEMBL10105619 | 0.79 | PARP1 (0.44) | HPGDKDM4EBCAT2SMN1; SMN2LMNA | |
| Cariporide SCHEMBL39639 | 0.79 | SLC9A1 (0.61) | PLAUSCN5ASCN2ACA1CA2 | |
| Hydrochloric Acid SCHEMBL8504318 | 0.79 | PLAU (0.38) | PLAUSCN5ASCN2A | |
| Hydrochloric Acid SCHEMBL8816752 | 0.78 | SLC9A1 (0.47) | PLAUCA1CA2 | |
| Cariporide SCHEMBL1229789 | 0.78 | SLC9A1 (0.60) | PLAUSCN5ASCN2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |