SCHEMBL8767280

SCHEMBL8767280

CCc1cc(C2(c3ccc(Cc4ccc(N)cc4)c(CC)c3)CCCCC2)ccc1Cc1ccc(N)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ESR1 P03372 3/20 0.38
ESR2 Q92731 3/20 0.38
LMNA P02545 3/20 0.36
ALOX12 P18054 3/20 0.36
PPARA Q07869 1/20 0.36
DHFR P00374 1/20 0.35
CYP3A4 P08684 3/20 0.35
TSHR P16473 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.34
CYP19A1 P11511 4/20 0.33
CYP17A1 P05093 1/20 0.33
CYP11A1 P05108 1/20 0.33
TBXAS1 P24557 1/20 0.33
PMP22 Q01453 1/20 0.33
PDE4D Q08499 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8766537 0.89 ALDH1A1 (0.49) ALDH1A1L3MBTL1ESR1ESR2LMNA
SCHEMBL8765946 0.85 ALDH1A1 (0.34) ALDH1A1L3MBTL1DHFRCYP3A4TSHR
SCHEMBL8767260 0.85 ALDH1A1 (0.34) ALDH1A1L3MBTL1DHFRCYP3A4TSHR
SCHEMBL8766394 0.84 ALDH1A1 (0.53) ALDH1A1L3MBTL1ESR1ESR2LMNA
SCHEMBL8765969 0.82 CYP19A1 (0.32) ALDH1A1L3MBTL1DHFRCYP3A4TSHR
SCHEMBL8766411 0.82 ALDH1A1 (0.53) ALDH1A1L3MBTL1ESR1ESR2LMNA
SCHEMBL11890474 0.79 ALDH1A1 (0.71) ALDH1A1L3MBTL1ESR1ESR2LMNA
SCHEMBL1305524 0.78 ALDH1A1 (0.77) ALDH1A1L3MBTL1ESR1ESR2LMNA
SCHEMBL31175767 0.77 TSHR (0.50) ALDH1A1DHFRCYP3A4TSHRTDP1
SCHEMBL2596069 0.77 TSHR (0.50) ALDH1A1DHFRCYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601813-B1 Diamino compounds and their production method and liquid crystal alignment layers using the compounds CHISSO CORP (JP) 1997-08-13 EP disclosed
US-5382688-A Diamino compounds and their production method CHISSO CORPORATION (JP) 1995-01-17 US disclosed
EP-0601813-A1 Diamino compounds and their production method and liquid crystal alignment layers using the compounds CHISSO CORPORATION (JP) 1994-06-15 EP disclosed