Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829520 | 0.98 | TRPV1 (0.53) | NAAATRPV1MAPK1ALDH1A1ERCC1 | |
| SCHEMBL3200580 | 0.87 | ERCC1 (0.52) | TRPV1ALDH1A1ERCC1ERCC4 | |
| SCHEMBL14540295 | 0.87 | ERCC1 (0.52) | TRPV1ALDH1A1ERCC1ERCC4 | |
| SCHEMBL1231957 | 0.84 | CNR1 (0.65) | NAAAMAPK1CYP2D6CYP2C19 | |
| SCHEMBL5842738 | 0.83 | TRPV1 (0.56) | NAAATRPV1ALDH1A1ERCC1ERCC4 | |
| SCHEMBL22118182 | 0.82 | MAPK1 (0.51) | NAAAMAPK1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL5611870 | 0.81 | ALDH1A1 (0.53) | NAAATRPV1ALDH1A1ERCC1ERCC4 | |
| SCHEMBL13593278 | 0.81 | NAAA (0.54) | NAAAMAPK1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL11471099 | 0.79 | GLI1 (0.59) | TRPV1ALDH1A1ERCC1ERCC4KMT2A | |
| SCHEMBL28658959 | 0.79 | GPR88 (0.56) | NAAATRPV1ALDH1A1ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781268-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |