Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8505884 | 0.99 | F2 (0.44) | F2PRSS1PRSS2PRSS3ST14 | |
| Hydrochloric Acid SCHEMBL8506593 | 0.88 | BRAF (0.43) | F2SCN8ASCN10ABRAFHDAC3 | |
| Hydrochloric Acid SCHEMBL8503960 | 0.88 | STK39 (0.45) | SCN9AHDAC1HDAC8HDAC6PARP10 | |
| SCHEMBL8070147 | 0.86 | TSHR (0.40) | — | |
| SCHEMBL27352801 | 0.85 | LMNA (0.43) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL8059411 | 0.85 | HDAC3 (0.39) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL8061430 | 0.85 | MRGPRX1 (0.40) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL8181853 | 0.84 | SLC6A2 (0.37) | SCN9ABRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL8181852 | 0.83 | SCN9A (0.38) | SCN9ABRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL8074970 | 0.82 | SLC6A2 (0.45) | SCN9ABRAFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |