Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9111522 | 0.90 | ALDH1A1 (0.54) | MAPTTSHRALDH1A1 | |
| SCHEMBL8769000 | 0.84 | PSEN1 (0.44) | MAPTCYP3A4ALDH1A1 | |
| SCHEMBL8768174 | 0.77 | ALDH1A1 (0.56) | MAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL9108722 | 0.76 | MAPT (0.51) | MAPTTSHRKDM4ETP53CYP3A4 | |
| SCHEMBL8767887 | 0.76 | PPARA (0.43) | MAPTTSHRKDM4ECYP3A4ALDH1A1 | |
| SCHEMBL8768911 | 0.75 | PPARA (0.48) | TSHRCYP3A4ALDH1A1 | |
| SCHEMBL8768112 | 0.74 | PPARA (0.56) | MAPTTSHRKDM4ETP53CYP3A4 | |
| SCHEMBL8768851 | 0.73 | PPARA (0.67) | MAPTTSHRKDM4ETP53CYP3A4 | |
| SCHEMBL8856463 | 0.72 | KDM4E (0.63) | MAPTTSHRKDM4ETP53CYP3A4 | |
| SCHEMBL8856424 | 0.71 | KDM4E (0.63) | MAPTTSHRKDM4ETP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |