Sugi Predict

Sugi Predict / Compounds / SCHEMBL8768340

SCHEMBL8768340

SCHEMBL8768340

O=C(Nc1ccccc1)c1ccc(-c2nc3cc(NC(=O)c4ccccc4)ccc3[nH]2)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 5/20 0.77
▸ MMP9 P14780 5/20 0.77
▸ MMP8 P22894 5/20 0.77
▸ MMP13 P45452 5/20 0.77
▸ HPSE Q9Y251 3/20 0.75
▸ COMT P21964 1/20 0.69
▸ CHEK2 O96017 1/20 0.68
▸ MEN1 O00255 3/20 0.67
▸ RAB9A P51151 3/20 0.67
▸ KMT2A Q03164 3/20 0.67
▸ KDM4E B2RXH2 3/20 0.67
▸ NPC1 O15118 2/20 0.67
▸ POLB P06746 2/20 0.67
▸ MAPT P10636 2/20 0.67
▸ THRB P10828 1/20 0.67
▸ RECQL P46063 1/20 0.67
▸ ATM Q13315 1/20 0.67
▸ NR2E3 Q9Y5X4 1/20 0.65
▸ PRMT5 O14744 1/20 0.61
▸ PRSS12 P56730 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8767467 0.97 MMP2 (0.81) MMP2MMP9MMP8MMP13HPSE
SCHEMBL14381542 0.95 MMP2 (0.77) MMP2MMP9MMP8MMP13HPSE
SCHEMBL8769518 0.94 HPSE (0.73) MMP2MMP9MMP8MMP13HPSE
SCHEMBL19174176 0.94 MMP2 (0.74) MMP2MMP9MMP8MMP13HPSE
SCHEMBL14381672 0.93 HPSE (0.69) MMP2MMP9MMP8MMP13HPSE
Hydrochloric Acid SCHEMBL19149751 0.93 MMP2 (0.73) MMP2MMP9MMP8MMP13HPSE
SCHEMBL14381718 0.92 MMP2 (0.69) MMP2MMP9MMP8MMP13HPSE
SCHEMBL8769488 0.92 MMP2 (0.65) MMP2MMP9MMP8MMP13HPSE
SCHEMBL6258284 0.91 MMP2 (0.74) MMP2MMP9MMP8MMP13HPSE
SCHEMBL3919993 0.90 HPSE (0.71) MMP2MMP9MMP8MMP13HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9622991-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2017-04-18 — — US disclosed
US-9622991-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2017-04-18 — — US disclosed
US-9144557-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2015-09-29 — — US disclosed
US-9144557-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2015-09-29 — — US disclosed
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-09-10 — — US disclosed
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-09-10 — — US disclosed
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-08-28 — — US disclosed
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-08-28 — — US disclosed
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2012-11-22 — — US disclosed
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2012-11-22 — — US disclosed
WO-2012068406-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2012-05-24 — — WO disclosed
WO-2011046954-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2011-04-21 — — WO disclosed
US-7282518-B2 Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation AVANIR PHARMACEUTICALS (US) 2007-10-16 — — US disclosed
US-7282518-B2 Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation AVANIR PHARMACEUTICALS (US) 2007-10-16 — — US disclosed
US-20070202133-A1 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION SIRCAR JAGADISH C 2007-08-30 — — US disclosed
US-20070202133-A1 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION SIRCAR JAGADISH C 2007-08-30 — — US disclosed
EP-1368028-B1 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION AVANIR PHARMACEUTICALS (US) 2007-08-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070202133-A1 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION MKI67, CMA1, CCNI MMP2 760/4885MMP9 1867/4885MMP8 423/4885
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS HGF, EPOR, MPL MMP2 2911/4885MMP9 4364/4885MMP8 1058/4885
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF MMP2 3334/4885MMP9 3464/4885MMP8 412/4885
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF MMP2 3334/4885MMP9 3464/4885MMP8 412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.