Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.69 |
| ▸ | PPARG | P37231 | 8/20 | 0.69 |
| ▸ | PPARD | Q03181 | 3/20 | 0.69 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923385 | 0.91 | PPARA (0.70) | PPARAPPARGPPARDHDAC6HDAC3 | |
| SCHEMBL8768812 | 0.90 | PPARA (0.56) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL8768869 | 0.90 | PPARA (0.56) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL8768086 | 0.87 | PPARA (0.61) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL8768666 | 0.87 | PPARA (0.57) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL8767844 | 0.85 | PPARA (0.58) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL9258955 | 0.82 | CNR2 (0.53) | PPARAPPARGPPARDCYP1A2CYP3A4 | |
| SCHEMBL13018713 | 0.82 | HDAC6 (0.67) | CNR2HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL3967402 | 0.82 | PPARA (1.00) | PPARAPPARGPPARDSOAT1 | |
| SCHEMBL8767753 | 0.82 | PPARA (0.62) | PPARAPPARGPPARDHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |