Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260018 | 0.90 | HDAC6 (0.47) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL8768166 | 0.85 | CCKBR (0.52) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL8768663 | 0.82 | PPARA (0.69) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL8768869 | 0.82 | PPARA (0.56) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL8768812 | 0.82 | PPARA (0.56) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL13018713 | 0.81 | HDAC6 (0.67) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL9252062 | 0.81 | SOAT1 (0.48) | CNR2HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL9435552 | 0.80 | GAA (0.56) | CNR2PPARGPPARDPPARAMAPT | |
| SCHEMBL9260772 | 0.79 | SOAT1 (0.70) | PPARGPPARDPPARASOAT1 | |
| SCHEMBL10889452 | 0.78 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422373-A | An alkoxybenzyl-alkylene-arylurea anticholesterol, antilipemic agents and enzyme inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0550568-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006075-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |