Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418501 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1HTTHPGDMAPT | |
| SCHEMBL10780306 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HTTHPGDPLA2G2A | |
| SCHEMBL9760147 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1HTTHPGDPLA2G2A | |
| SCHEMBL8822991 | 0.77 | KMT2A (0.66) | KDM4EALDH1A1HTTHPGDPLA2G2A | |
| SCHEMBL9728952 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTMAPK1 | |
| SCHEMBL13134040 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HTTHPGDPTGS2 | |
| SCHEMBL12398530 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1HTTHPGDMAPT | |
| SCHEMBL31277886 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1HTTHPGDMAPT | |
| SCHEMBL31278019 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1HTTHPGDMAPT | |
| SCHEMBL8823005 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1HTTHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654035-B1 | PHOSPHONOACETIC ESTERS AND ACIDS AS ANTI-INFLAMMATORIES | UPJOHN CO (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5643895-A | Phosphonoacetic esters and acids as anti-inflammatories | THE UPJOHN COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5565441-A | AN N-HETEROCYCLE DERIVATIVE; ANTIARTHRITIC AGENTS; DISEASES CHARACTERIZED BY ABNORMAL PHOSPHATE AND CALCIUM METABOLISM; CHRONIC DISEASES | THE UPJOHN COMPANY (US) | 1996-10-15 | — | — | US | disclosed |