Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
| ▸ | CBFB | Q13951 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888873 | 0.81 | MAPT (0.56) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL23460193 | 0.81 | L3MBTL1 (0.45) | KDM4ETSHRHTR6APOBEC3AMEN1 | |
| SCHEMBL13134040 | 0.80 | KDM4E (0.51) | KDM4ETSHRHSD17B10HTR6MEN1 | |
| SCHEMBL38666647 | 0.77 | PIK3CG (0.50) | KDM4ETSHRHSD17B10HTR6MEN1 | |
| SCHEMBL22330396 | 0.74 | KDM4E (0.46) | KDM4ETSHRHSD17B10HTR6MEN1 | |
| SCHEMBL14350206 | 0.73 | CRHR1 (0.63) | — | |
| SCHEMBL8768671 | 0.73 | KDM4E (0.66) | KDM4ETSHRHSD17B10HTR6MEN1 | |
| SCHEMBL18208780 | 0.72 | KDM4E (0.55) | KDM4ETSHRHSD17B10HTR6APOBEC3A | |
| SCHEMBL8822948 | 0.70 | HTR6 (0.46) | KDM4ETSHRHSD17B10HTR6MEN1 | |
| SCHEMBL15613276 | 0.70 | KDM4E (0.75) | KDM4ETSHRHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0521622-B1 | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories | UPJOHN CO (US) | 1997-08-13 | — | — | EP | disclosed |
| US-5635495-A | ANTIARTHRITIC AGENTS TREATING BONE DISORDER, OSTEOPOROSIS; CALCIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1997-06-03 | — | — | US | disclosed |
| EP-0593575-B1 | PYRAZOLOPYRIMIDINE AND PYRIMIDINYL BISPHOSPHONIC ESTERS AS ANTI-INFLAMMATORIES | UPJOHN CO (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5397774-A | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories | THE UPJOHN COMPANY (US) | 1995-03-14 | — | — | US | disclosed |
| EP-0593575-A1 | PYRAZOLOPYRIMIDINE AND PYRIMIDINYL BISPHOSPHONIC ESTERS AS ANTI-INFLAMMATORIES. | UPJOHN CO (US) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993001198-A1 | PYRAZOLOPYRIMIDINE AND PYRIMIDINYL BISPHOSPHONIC ESTERS AS ANTI-INFLAMMATORIES | THE UPJOHN COMPANY (US) | 1993-01-21 | — | — | WO | disclosed |
| EP-0521622-A1 | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories | THE UPJOHN COMPANY (US) | 1993-01-07 | — | — | EP | disclosed |