Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | FES | P07332 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768882 | 0.79 | CXCR2 (0.50) | CXCR2FLT4KDRFESFGFR1 | |
| SCHEMBL8349873 | 0.78 | L3MBTL1 (0.58) | LMNACCNCCDK8CDKN1ACDK19 | |
| SCHEMBL30673020 | 0.77 | CNR1 (0.46) | CXCR2FLT4KDRFESFGFR1 | |
| SCHEMBL4364173 | 0.74 | FLT4 (0.79) | CXCR2FLT4KDRFESFGFR1 | |
| SCHEMBL30673004 | 0.74 | MEN1 (0.62) | CXCR2LMNAFLT4KDRFES | |
| SCHEMBL30513604 | 0.74 | GRM4 (0.48) | CXCR2LMNAFLT4KDRMAPKAPK2 | |
| SCHEMBL28652875 | 0.74 | GRM4 (0.48) | CXCR2LMNAFLT4KDRMAPKAPK2 | |
| SCHEMBL4370740 | 0.73 | FLT4 (0.56) | CXCR2FLT4KDRFESFGFR1 | |
| SCHEMBL4366404 | 0.73 | FES (0.56) | CXCR2FLT4KDRFESFGFR1 | |
| SCHEMBL8868951 | 0.73 | MAPKAPK2 (0.59) | CXCR2MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789690-A1 | N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1996014300-A1 | N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-17 | — | — | WO | disclosed |