Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517237 | 0.88 | HSD17B10 (0.47) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| Hydrochloric Acid SCHEMBL6888155 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| SCHEMBL28802737 | 0.79 | TDP1 (0.49) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| SCHEMBL9030269 | 0.79 | HSD17B10 (0.45) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| SCHEMBL4216264 | 0.67 | HSD17B10 (0.48) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| SCHEMBL3319952 | 0.64 | HSD17B10 (0.42) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| SCHEMBL572749 | 0.64 | HSD17B10 (0.46) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| Bromide SCHEMBL9444674 | 0.64 | HTR1A (0.54) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| SCHEMBL16395801 | 0.64 | HSD17B10 (0.42) | ALDH1A1HSD17B10HTR3EHTR3BCYP1A2 | |
| Naphthalene SCHEMBL27821444 | 0.63 | CYP2A6 (0.50) | ALDH1A1HSD17B10TSHRLMNARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571671-B1 | A Pharmaceutical composition in powder form | PROCTER & GAMBLE (US) | 1997-09-17 | — | — | EP | claimed |
| WO-1994005330-A1 | NASAL SPRAY PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-17 | — | — | WO | claimed |
| WO-1993024149-A1 | PHARMACEUTICAL POWDER COMPOSITION CONTAINING NON-IONIC CELLULOSE ETHER DERIVATIVE AND A CHITIN-DERIVED POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 1993-12-09 | — | — | WO | claimed |
| EP-0571671-A1 | A Pharmaceutical composition in powder form | THE PROCTER & GAMBLE COMPANY (US) | 1993-12-01 | — | — | EP | claimed |
| EP-0571671-B1 | A Pharmaceutical composition in powder form | PROCTER & GAMBLE (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1994005330-A1 | NASAL SPRAY PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-17 | — | — | WO | disclosed |
| WO-1993024149-A1 | PHARMACEUTICAL POWDER COMPOSITION CONTAINING NON-IONIC CELLULOSE ETHER DERIVATIVE AND A CHITIN-DERIVED POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 1993-12-09 | — | — | WO | disclosed |
| EP-0571671-A1 | A Pharmaceutical composition in powder form | THE PROCTER & GAMBLE COMPANY (US) | 1993-12-01 | — | — | EP | disclosed |
| EP-0023359-B1 | POWDERY PHARMACEUTICAL COMPOSITION AND POWDERY PREPARATION FOR APPLICATION TO THE NASAL MUCOSA, AND METHOD FOR ADMINISTRATION THEREOF | TEIJIN LIMITED (JP) | 1984-04-18 | — | — | EP | disclosed |