Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341124 | 0.81 | PDE4A (0.78) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7341287 | 0.80 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2958828 | 0.79 | RECQL (0.60) | PDE4APDE4DPDE4BPDE4CRECQL | |
| SCHEMBL7332241 | 0.78 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7365454 | 0.78 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| Bromide SCHEMBL7370237 | 0.78 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL14578975 | 0.78 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL27558495 | 0.77 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL9266969 | 0.77 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CRECQL | |
| SCHEMBL7420229 | 0.77 | LDHA (0.60) | PDE4APDE4DPDE4BPDE4CRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |