Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 11/20 | 0.56 |
| ▸ | TPH1 | P17752 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422501 | 0.89 | PDE4B (0.52) | LDHAPDE4ATPH1PDE4BPDE4D | |
| SCHEMBL10879303 | 0.84 | LDHA (0.84) | LDHA | |
| SCHEMBL2371289 | 0.81 | PDE4B (0.60) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| Bicarbonate SCHEMBL7091204 | 0.80 | CSNK2A1 (0.58) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL5345025 | 0.79 | PDE4A (0.54) | PDE4ATPH1PDE4BPDE4DPDE4C | |
| SCHEMBL5345029 | 0.79 | PDE4A (0.54) | PDE4ATPH1PDE4BPDE4DPDE4C | |
| SCHEMBL7335293 | 0.79 | PDE4A (0.58) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL8157358 | 0.79 | HDAC1 (0.56) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL20721728 | 0.78 | LDHA (0.78) | LDHA | |
| SCHEMBL27558495 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248769-B1 | ANTIINFLAMMATORY AGENT | EURO-CELTIQUE S.A. (LU) | 2001-06-19 | — | — | US | disclosed |
| US-6103749-A | PHENYL IMIDAZOLE COMPOUNDS USEFUL FOR TREATMENT OF ASTHMA, ALLERGIES, INFLAMMATION AND DEPRESSION | EURO-CELTIQUE S.A. (LU) | 2000-08-15 | — | — | US | disclosed |
| EP-0766676-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-07-08 | — | — | EP | disclosed |
| EP-0766676-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-04-09 | — | — | EP | disclosed |
| WO-1996000218-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-01-04 | — | — | WO | disclosed |