Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA5A | P35218 | 3/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696390 | 0.90 | STAT3 (0.39) | SCN9ASTAT3PTGES2CA2CA1 | |
| SCHEMBL8770171 | 0.88 | SCN9A (0.45) | SCN9ASTAT3PTGES2CA2CA1 | |
| SCHEMBL6917671 | 0.88 | FABP4 (0.44) | STAT3PTGES2CA2CA1CA5A | |
| SCHEMBL8661463 | 0.83 | PTGES2 (0.39) | SCN9ASTAT3PTGES2CA2CA1 | |
| SCHEMBL8657585 | 0.83 | PTGES2 (0.41) | STAT3PTGES2CA2CA1CA5A | |
| SCHEMBL8663230 | 0.83 | F10 (0.41) | PTGES2FABP4 | |
| SCHEMBL2452803 | 0.82 | SCN9A (0.48) | SCN9APTGES2CA2CA1CA5A | |
| SCHEMBL8662840 | 0.82 | PTGES2 (0.38) | STAT3PTGES2CA2CA1CA5A | |
| SCHEMBL7696386 | 0.82 | SCN9A (0.40) | SCN9ASTAT3PTGES2MEN1KMT2A | |
| SCHEMBL8662997 | 0.81 | PTGES2 (0.51) | PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |