Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770262 | 0.84 | ITGB3 (0.58) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL8770224 | 0.84 | ITGB3 (0.58) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL8770331 | 0.80 | F2 (0.39) | ITGB3ITGA2BITGB1F2PRSS1 | |
| SCHEMBL8904649 | 0.76 | ITGB3 (0.53) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL8770327 | 0.76 | NPC1 (0.43) | ITGB1F2PRSS1TMPRSS6 | |
| SCHEMBL8770225 | 0.74 | ITGB3 (0.49) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL7821019 | 0.74 | ITGB3 (0.68) | ITGB3ITGA2BF2PRSS1F10 | |
| SCHEMBL8770638 | 0.73 | NPC1 (0.51) | ITGB3ITGA2BF2PRSS1F10 | |
| SCHEMBL8770227 | 0.73 | NPC1 (0.51) | ITGB3ITGA2BF2PRSS1F10 | |
| Iodide SCHEMBL7831865 | 0.73 | ITGB3 (0.67) | ITGB3ITGA2BF2PRSS1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |