Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537547 | 0.84 | AKR1B1 (0.42) | PTGS2 | |
| SCHEMBL4860115 | 0.84 | PTGS2 (0.57) | PTGS2PTGS1ALOX5 | |
| SCHEMBL937206 | 0.84 | PTGS2 (0.61) | PTGS2ACLYPTGS1RAB9AKMT2A | |
| SCHEMBL29415408 | 0.84 | PTGS2 (0.61) | PTGS2ACLYPTGS1RAB9AKMT2A | |
| SCHEMBL29700169 | 0.83 | PTGS2 (0.52) | PTGS2ACLYPTGS1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7352630 | 0.82 | PTGS2 (0.59) | PTGS2ACLYPTGS1RAB9AKMT2A | |
| SCHEMBL11133788 | 0.81 | PTGS2 (0.39) | PTGS2PTGS1RAB9AKMT2AL3MBTL1 | |
| SCHEMBL8909039 | 0.81 | HNF4A (0.43) | PTGS2 | |
| SCHEMBL8770061 | 0.81 | PTGS2 (0.50) | PTGS2ACLYPTGS1L3MBTL1 | |
| SCHEMBL4198455 | 0.80 | PTGS2 (0.62) | PTGS2ACLYPTGS1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | claimed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | claimed |