Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 9/20 | 0.45 |
| ▸ | F7 | P08709 | 8/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | PLAU | P00749 | 3/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770674 | 0.89 | NPC1 (0.51) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770226 | 0.89 | NPC1 (0.51) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770394 | 0.86 | NPC1 (0.48) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770352 | 0.85 | NPC1 (0.49) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770262 | 0.77 | ITGB3 (0.58) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770224 | 0.77 | ITGB3 (0.58) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770302 | 0.76 | F2 (0.49) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770227 | 0.75 | NPC1 (0.51) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770638 | 0.75 | NPC1 (0.51) | NPC1RAB9AF2F7F10 | |
| SCHEMBL8770242 | 0.73 | EPHX2 (0.51) | NPC1RAB9AF2F10PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | claimed |