Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 9/20 | 0.46 |
| ▸ | F10 | P00742 | 5/20 | 0.46 |
| ▸ | PLAU | P00749 | 5/20 | 0.46 |
| ▸ | PLAT | P00750 | 3/20 | 0.46 |
| ▸ | F7 | P08709 | 9/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770674 | 0.86 | NPC1 (0.51) | NPC1RAB9AF2F10PLAU | |
| SCHEMBL8770226 | 0.86 | NPC1 (0.51) | NPC1RAB9AF2F10PLAU | |
| SCHEMBL8770281 | 0.85 | NPC1 (0.50) | NPC1RAB9AF2F10PLAU | |
| SCHEMBL11860402 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2A | |
| SCHEMBL19489229 | 0.84 | SMN1; SMN2 (0.58) | F2F10PLAUF7PRSS1 | |
| SCHEMBL19486253 | 0.84 | SMN1; SMN2 (0.58) | F2F10PLAUF7PRSS1 | |
| SCHEMBL19486247 | 0.84 | SMN1; SMN2 (0.58) | F2F10PLAUF7PRSS1 | |
| SCHEMBL8770394 | 0.83 | NPC1 (0.48) | NPC1RAB9AF2F10PLAU | |
| SCHEMBL8770224 | 0.79 | ITGB3 (0.58) | NPC1RAB9AF2F10PLAU | |
| SCHEMBL8770262 | 0.79 | ITGB3 (0.58) | NPC1RAB9AF2F10PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | claimed |